From the ashes of old conflicts, a new terror arises. The Umbrella Corporation and its crop of lethal viruses have been destroyed and contained. But a new, more dangerous threat has emerged. Years after surviving the events in Raccoon City, Chris Redfield has been fighting the scourge of bio-organic weapons all over the world. Now a member of the Bio-terrorism Security Assessment Alliance (B.S.A.A.), Chris is sent to Africa to investigate a biological agent that is transforming the populace into aggressive and disturbing creatures.

In a not too distant future, the rapid advancement of technology has allowed mans common dream of colonizing distant planets become reality. With need of further natural resources and living space, the human race rapidly expands. Unprepared for the scale of development, the Federation, overseer for the process of colonizing the universe, limit the selling of terra forming permits.

Game retells the original story, but with some new twists. Dr. West is now a teacher Rick and Jennifer. It is the main villain games and sends the monsters to kidnap girl and fatally wound Riku, Mask of terror. Now our hero to save their beloved.